Biventricular Global Function Index Is Associated With Adverse Outcomes in Repaired Tetralogy of Fallot

Introduction: Cardiac magnetic resonance (CMR) derived biventricular global function index (BVGFI) is a new CMR parameter that integrates volumes, mass, and using clinically available parameters. The associations of BVGFI with clinical outcomes in repaired tetralogy Fallot are unknown. Methods: Patients who had before the occurrence composite outcome death, resuscitated sudden or sustained ventricular tachycardia were studied. was calculated as average right left GFI. GFI defined (ventricular stroke volume×100)/(ventricular mean cavity volume + total myocardial volume). Ventricular ([end-diastolic end-systolic volume]/2). Cox multivariable regression analysis classification tree methodology used. Results: Of 736 eligible subjects (mean age at 25.4±14.5 years), median follow-up 28 months, 55 (7.4%) reached (46 deaths 9 tachycardia). Independent follows: <37 (hazard ratio, 2.52; P =0.004), >85 mL/m 2 3.25; <0.001), atrial 2.03; =0.021), repair >2.5 years 3.37; <0.001). Classification identified most discriminatory associated high risk for adverse outcomes. Conclusions: BVGFI, novel CMR-derived imaging biomarker combining function, may improve stratification patients Fallot.